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Introduction |
Treatment |
What is Cancer ? |
Side-effects of treatment |
What causes Cancer ? |
Prevention |
Warning signals of Cancer in Women |
Role of food in fighting Cancer |
Different types of Cancer in Women |
Cancer Research - the light ahead |
Breast Cancer |
Questions a cancer patient can ask the doctor |
Cancer of the Cervix, Uterus & Ovary |
Glossary |
Screening for Cancer |
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| Introduction |
Cancer is one of the frequently talked about and most feared disease that falls under the genre of lifestyle diseases that have evolved, rather rapidly, in the past two decades. The disease, which was earlier - in its initial years of discovery - dubbed as the death sentence for the person diagnosed with it, has now become more manageable, thanks to the fervent efforts of researchers and oncologists. Though science has made rapid strides to evolve many preventive and curative strategies to fight cancer, it has not been able to break the fear and confusion that surrounds a person when diagnosed with the disease.
One of the recent concerns plaguing the field of cancer study or Oncology is the increasing number of women who are being diagnosed with Cancer. It is estimated that the number of cervical cancer deaths in women in India is likely to rise to 79,000 by the year 2010, while the number of deaths due to breast cancer and oral cancer would rise to 59,000 and 53,000 respectively. While breast cancer is the most common cancer among women, cervical cancer comes a close second and is a leading cause of cancer-related death in women in underdeveloped countries. Studies further confirm that the world over, for all cancers combined, prevalence in women is higher than in men.
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What is Cancer ? |
Cancer, in simple terms, occurs when cells divide in an uncontrolled manner. The
human body is made up of different tissues and each tissue has its individual
cellular structure. The cells in the tissues are lost through wear and tear and
are constantly replaced by a process called cell division. Normally, cells
divide - and produce the exact number of cells required - only when the body
needs more cells. In cancer, however, cells divide for no apparent reason. In
time, they form a mass of extra tissue and become big enough to be noticed as a
growth or tumour.
A tumour can be benign - harmless - or malignant - bad. Benign tissues are rarely a threat to life, unless in a major organ. These do not invade the surrounding tissue and do not spread. They can usually be removed and do not come back. But malignant tumours grow into the surrounding tissue in a process called invasion. Cancer cells also break away from a malignant tumour and enter the blood stream or lymphatic system. This is how cancer spreads from the original tumour to other tissues and organs. The spread of cancer is called metastasis.
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What causes Cancer ? |
Though the exact cause is unknown, there are various theories on what could lead to the condition. The viral theory says that a cell becomes cancerous when infected by a virus. The immunological theory says that an abnormal cell survives to become a cancer because the body's defenses somehow break down. The chemical theory rests on the evidence from animal tests that certain chemicals cause cancer by altering the genetic make-up of a cell. These are known as carcinogens; tobacco smoke is one. Relation is also known to cause cancer. Cancer has many causes, some of which are still unknown.
However, research on cancer continues. Using the molecular data from the Human Genome Project, scientists at the Cancer Research Centre at Massachusetts Institute of Technology have identified the gene-rhoC-that causes cancer cells to break away from the original tumour and form new tumours in other parts of the body. This gene triggers the sequence of events that lead to a secondary tumour.
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Warning signals of Cancer in Women |
Unusual bleeding or discharge. Blood in the vaginal discharge or bleeding after intercourse.
A lump in the breast or elsewhere.
A sore that does not heal.
Changes in bowel or bladder habits.
Hoarseness or cough.
Indigestion or difficulty in swallowing.
Change in the size of a birthmark or mole. |
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Different types of Cancer in Women |
Women who are aged between 20 and 40 years should make it necessary to get themselves checked for cancer every three years apart from regular easy-to-do home examinations to stay alert to warning signs of cancer. For cancer, be it of the breast or the uterus, can be cured if detected early enough.
Some cancers that are common in women are oral cancer, oesophageal cancer, leukaemia, buccal mucosa, malignant lymphoma and thyroid cancer, besides breast cancer and cancer of the reproductive system.
Leukaemia : Commonly known as blood cancer and characterized by tumors in the bone marrow. In this condition, an abnormally large number of white blood cells are produced, thereby inhibiting the production of blood cells. Causes could be radiation, exposure to certain chemicals, a certain virus, drugs and hereditary factors. Symptoms include low fever and anaemia, loss of weight and appetite. Treatment involves radiation therapy, chemotherapy and surgery to remove enlarged spleen. Bone marrow transplant is also recommended.
Oral Cancer : Caused by radiation, excessive exposure to sunlight, sharp edges of broken teeth brushing against the inner lining of the mouth, chewing tobacco and high deficiency of Vitamins A and B. Symptoms include white or red patches in the mouth, sores that don't heal even after treatment, thickening or hardening or swelling in the mouth and difficulty in opening the mouth. Radiation therapy and surgery followed by radiation are the common modes of treatment.
Oesophageal Cancer : This type is quite common in India. Food habits are the main cause; consumption of very hot or very cold food, spices, chillies, animal fat, preserved meat and fish, paan, deficiency of Vitamins A and B, exposure to radiation and virus. Symptoms include difficulty in swallowing, weight loss, loss of appetite, vomiting, blood in the stool, which is dark in colour.
Lymphoma : Malignant tumors of the lymph nodes, most often in the lymph nodes of the alimentary canal, thymus and bone marrow. Also occurs in the brain, liver and kidney. Lymphomas are of two kinds. Hodgkin's disease and non-Hodgkin's disease. Symptoms are low fever and anemia, swelling of glands most often on one side of the neck, loss of weight and appetite, and weakness. Chemotherapy and radiation is possible in both cases. Surgery to remove affected lymph glands is possible only in Hodgkin's disease. |
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Breast Cancer |
Breast Cancer, which is the second most common cancer makes up for almost nine per cent of all new cancer cases in India. It occurs when cells of the breast grow and multiply in an uncontrolled manner. Though the exact cause still eludes scientists, the abnormal cell division appears to be the result of some mutation in the cell's DNA. However, a number of risk factors have been identified which could help women stay alert.
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Age
The risk of breast cancer increases with age; a 70- year-old woman is more vulnerable than a 40-year-old. Therefore, it is important that all women above 50 undergo regular breast mammograms.
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Family history
Family history is an important risk factor for breast cancer. In families with a bad gene for breast cancer, around half of the female members develop the cancer, usually before 40 years of age. Often, both breasts are affected. On the other hand, if one or two women out of 20 family members develop breast cancer and both are above 60, then this probably does not increase the risk of breast cancer.
Reproductive factors
A woman who has had her first child before the age of 23 has one-third the risk of breast cancer compared with a woman who has her first baby at 30. Breast-feeding for at least three months has a protective effect.
The sooner cancer is diagnosed and treated, the better the patient's chances for a full recovery. For early detection it is necessary that the person has regular medical check-ups and does self-examinations. Women should talk to their doctors about this disease, the symptoms to watch for and check-ups.
| How often should a Women have Check-ups? |
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From age 35 self-examine your breasts once every month.
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From 40, continue self-examinations and have your doctor examine your breasts once a year.
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From age 50, get a mammogram done every two years. In addition, continue self-examination and check-ups by the doctor.
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Cancer of the Cervix, Uterus & Ovary |
Cancers can hit the uterus and the ovaries. Uterine cancer is of two types: cervical and endometrial.
Cervical cancer
Occurs in the cervix, the canal between the vagina and the uterus. This is the most common cancer among Indian women. |
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| You are more likely to be affected if you: |
- Have had sexual encounters at an early age
- Have multiple sexual partners
- Have poor genital hygiene
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| Watch out for: |
- Blood in vaginal discharge
- Unusual bleeding between periods
- Unusual bleeding after intercourse
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| Help at hand |
The cervix can be removed through surgery, if the cancer has not spread to other parts of the body. Radiotherapy is useful in the second and third stages.
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| Precautions |
The Pap test detects signs of cervical cancer early on. Have a Pap test every year if you are:
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Endometrial Cancer
Occurs within the uterus. Usually occurs among older women and is influenced by genetic predisposition to the disease.
You are more likely to be affected if
you: |
- Are over 40
- Are overweight
- Take hormones
- Are infertile
- Do not ovulate
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| Watch out for: |
- Blood in vaginal discharge
- Abnormal bleeding - bleeding other than menstrual flow
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| Help at hand |
If only the uterus has been affected, a hysterectomy (surgical removal of the uterus) helps. If the cancer has spread, the surgery must be followed up with radiotherapy. Chemotherapy is used in advanced conditions.
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Ovarian cancer
Occurs in the ovaries, which produces the ova or eggs. This type of cancer is common among older women.
| Watch out for: |
- Discomfort in the lower abdomen
- Swelling of the abdomen
- Loss of weight
- Back ache
- Occasional breathlessness
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| Help at hand |
The vast majority of women diagnosed with first and second stage ovarian cancer survive with proper treatment. If the cancer is caught in the first stage, cure is possible through surgery. This is supplemented with radiation for second-stage cancers. Chemotherapy is used only in the final stages. |
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Screening for Cancer |
A periodic health check is a woman's best bet against Cancer. Regular screening tests can detect cancer right in the beginning and intercepting the cancer early, means a more effective cure and a higher survival rate. While it is advisable that everyone go in for screening examinations regularly, this might not always be possible. But this is a must for people in high-risk groups.
Mammograms, breast examinations by a qualified medical professional and breast self-examinations (BSE) play an important role in detecting lumps and tumors early on. All lumps need not be cancerous - the doctor can diagnose cancer either through a biopsy or a cytological examination. A biopsy is done by removing part of the tumor, which is then examined by a pathologist to examine whether it is cancerous or not. In a cytological examination, body fluids are examined for cancer cells.
The Pap smear - also called Pap test - named after Dr. George N. Papanicolau, is the most effective advance warning in cases of cervical cancer. It not only detects cancers early but also spots precancerous conditions. The cells shed by the uterus are found in the vaginal fluid. These cells carry telltale signs of cancer or precancerous conditions. Examining a sample of the vaginal fluid helps identify abnormal cells, if any. In this procedure a few cells are scraped off the cervix, put on a microscope slide, dyed and examined.
Annual pelvic examinations - where the doctor feels the internal sex organs, bladder and rectum for abnormalities - can help spot endometrial cancer.
Once the cancer is detected, a whole lot of tests, like blood tests and X-rays, are done to check out the person's state of health and whether the cancer has spread to other parts of the body. Procedures like isotope scanning give a glimpse of inner organs and the stage of the cancer. Once the details of the cancer have been charted out, the doctor can decide on the right course of treatment.
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Treatment |
The method of treatment depends on the stage the cancer is in. However, every method has its side effects. Therefore, the choice of what treatment is to be used should be a judicious one. It is best if the patient discusses the course of treatment and associated side effects with the doctor before making a choice.
Surgery
Involves removing the tumor. The tissue surrounding the tumor and nearby lymph nodes could also be removed during the operation.
Radiation therapy
Also known as radiotherapy. High-energy rays are trained on the cancer cells to stop them from growing and multiplying. This is also local treatment, like surgery; it can affect cancer cells only in the treated area. There are two kinds of radiotherapy: external radiation, where the patient receives radiation from a machine, and internal radiation, where radiation comes from an implant placed directly into or near the tumor.
External radiation therapy is usually given on an outpatient basis in a hospital or clinic. Patients are not radioactive either during or after the treatment. In the case of internal radiation therapy, the patient has to be hospitalized for a few days. The implant may be temporary or permanent. Because the level of radiation is high, the patient may not be able to receive visitors while in hospital. Once the implant is removed, there is no radioactivity in the body. For permanent implants, the patient is allowed to leave, once the amount of radiation comes down to a safe level.
Chemotherapy
In this method, drugs are used to kill cancer cells. Anti cancer drugs are injected into a vein or a muscle; sometimes, it is also given orally. Chemotherapy is systemic treatment; the drugs enter the blood stream and reach nearly every part of the body.
The therapy generally happens in cycles: treatment period is followed by a recovery period, and so on. Usually, chemotherapy does not involve a hospital stay. However, this also depends on factors like which drugs are being used and patient's general health.
Hormone therapy
This works on cancers, like breast cancer, which need hormones to grow. The therapy prevents cancer cells from getting or using the hormones they need. This could involve surgery to remove organs - such as the ovaries - that make the hormones. Otherwise, drugs are used to stop hormone production or to change the way they act. This is also systemic treatment.
Biological therapy
Also called immunotherapy. Uses the patient's own immune system to fight the disease.
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Side-effects of treatment |
Often, cancer treatment results in damage to healthy cells and tissues, leading to unpleasant side effects. Side-effects depend upon the type and duration of the treatment. Also every person reacts differently to treatment.
A list of side effects generally associated with each treatment method.
Surgery: Depends on the location of the tumor, the type of operation, the patient's general health and other factors. Patients often feel pain for the first few days after surgery; this can be controlled with medicine. Patients may also feel tired or weak for a while.
Radiotherapy: Varies according to the treatment dosage and the part of the body that has been treated. Fatigue, skin reactions (like a rash or redness) in the treated area, and loss of appetite are common. There could also be a drop in the number of white blood cells, which help protect the body against infection. In most cases, the side effects are not permanent and the doctor can usually control them.
Chemotherapy: Depends on the drugs used and their dosages. Anti-cancer drugs affect cells that divide rapidly, especially blood cells which fight infection, help the clotting of blood or carry oxygen to the various parts of the body. If blood cells are affected, patients are likely to get infections, may bruise or bleed easily, and experience a loss of energy. As cells that line the digestive tract also divide rapidly, these may also be affected causing loss of appetite, nausea, vomiting, or mouth sores. These side effects often disappear in the recovery period or after treatment stops.
Patients are often concerned about chemo-related hair loss. Some drugs cause hair to thin out while others could lead to the loss of all body hair. It is best that the patient is informed beforehand and ways to handle hair loss discussed before treatment begins.
Loss of fertility, temporary or permanent, happens to some patients. Periods may stop and hot flushes and vaginal dryness are common. Periods are more likely to return in young women.
Hormone therapy: Patients may experience nausea and vomiting, swelling or weight gain, and, in some cases, hot flushes. Interrupted menstrual periods, vaginal dryness and loss of fertility could also happen. Changes may be temporary, long lasting or permanent.
Biological therapy: Depends on the type of treatment. Flu-like symptoms such as chills, fever, muscle aches, weakness, loss of appetite, nausea and diarrhoea, occur. Some develop a rash while others bruise or bleed easily. Patients may have to be hospitalized for treatment, if the problems are severe. These side effects are usually short-term and go away once treatment stops.
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Prevention |
Prevention is possible at two levels: primary and secondary. Primary level prevention is best characterized by the age old adage "Prevention is better than cure". This simply means, taking necessary precautions to avoid cancer. In secondary level prevention, mainly applicable to uterine-cervical and breast cancers, the spread of cancer can be controlled after early detection.
Some of the cancers that can be prevented at the primary level are oral cancer, lung cancer, and uterine and cervical cancers.
To avoid cancer :
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Don't smoke cigarettes. Avoid passive smoking, too. Cigarette smoking can cause lung cancer, besides heart disease, stomach ulcers, frequent colds and chronic bronchitis. Don't chew tobacco.
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Avoid alcohol. A woman who has two standard drinks a day (two glasses of wine or two nips of spirit) increases her risk of breast cancer by more than 50 per cent.
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Vary your diet to include foods low in fat and calories to keep you trim. Include fresh fruits, vegetables, sprouts, whole grains, whole grain breads and cereals in your daily diet.
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An apple a day, along with the doctor, could also keep cancer away. Scientists have found that extracts of apple with the skin left on slowed growth of cancer cells of colon and liver. They believe that the phytochemicals could be the cancer-inhibiting factors in the fruit.
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Exercise at least four hours a week. It need not be strenuous activity. Brisk walking is recommended. Being overweight is a risk factor for breast and uterine cancers.
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Excessive intake of fried foods, fat, preserved meat and burnt food could cause cancer.
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Avoid using heated oil over and over again for cooking. Also avoid artificial sweeteners and colouring agents in food. Clean vegetables and fruits thoroughly before use to remove pesticides.
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Personal hygiene is important. Especially oral hygiene, cleanliness of skin and genital hygiene.
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Early marriages and multiple pregnancies can lead to cancer of the uterus. Late first pregnancy may lead to cancer of the uterus or cervix.
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Avoid multiple sex partners.
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Avoid indiscriminate use of drugs. Always check with your doctor before taking medicines.
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Avoid too much sunlight, particularly if you are fairskinned. Wear protective clothing or use effective sunscreens.
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Avoid exposure to X-rays. Go for it only if your doctors recommend one.
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Take estrogens only as long as necessary. Discuss with your doctor about the duration of hormone replacement therapy.
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Role of food in fighting Cancer |
Creating 'good food habits' could be one of the easiest ways of fighting cancer. Oncologists and researchers have accepted the role that 'right food' can play, not only in regressing the advance of cancer but also in preventing it from occurring. The best diet to follow is one with lots of salads, vegetables, fruits, sprouts and nuts.
While diet alone cannot reverse the course of cancerous cells, it can deprive the tumors of its essentials. Carrots, grapes and soya beans have Cox-2 compounds which hinder the growth of new blood vessels, which are vital for the tumor to progress. Fruits and vegetables are rich in antioxidants which clean up free radicals (oxygen molecules generated by human activity which move around in the cells, stealing electrons from other molecules and triggering a tit-for-tat reaction which can damage DNA).
Dietary changes can also lower the risk for specific cancers. Up to 50 per cent of breast cancers, 33 per cent of lung cancers and 75 per cent of colon and rectal cancers can be avoided by following specific diets.
A tumor goes through three stages and food can play a beneficiary role in all the stages.
Stage I:- Initiation - An external or internal carcinogen induces changes in the genetic make-up of the cell. This creates a lesion which gives the cell the potential for tumorous growth.
Role of food: Diets high in vegetables and fruits, and the intake of food rich in bio-active compounds, trigger detoxification enzymes which, in turn, reduce the exposure of DNA to carcinogens.
- Onions and garlic have allium which has anticarcinogenic mechanisms.
- Cruiciferous vegetables like cabbage and cauliflower have dithiothiones which inhibits enzymes that activate carcinogens.
Stage II:- Promotion - At this stage, the prolific cells transform into a discernible group.
Role of food: The energy balance must be maintained as it will thwart the expansion of abnormal cells. Selenium and vitamin D have shown a protective effect against tumor promotion.
- Selenium (a mineral) is found in cereals, fish, liver and seafood. It has an antioxidant capacity and functions as a co-factor for glutathione peroxidase, an enzyme that prevents tissue damage.
- Vitamin D is present in milk, yogurt, curd, small fish (when eaten with their bones, like sardines) and egg yolk.
Stage III:- Progression - The local lesion transforms into an invasive tumor mass. There is widespread DNA damage. Ultimately there is metastasis, whereby tumor cells migrate to distant sites in the body.
Role of food: Folates in green, leafy vegetables and wholegrain cereals may help reduce damage to DNA. Fruits and vegetables have carotenoid (pigments) that have antioxidant properties.
- Beta-carotene is found in abundance in spinach, carrots, sweet potatoes and mangoes.
How different foods fight cancer
- Carrots - the antioxidants include alpha-carotene and beta-carotene
- Cauliflower - the indoles promote the production of enzymes that make the hormone estrogen less effective, reducing the risk of breast cancer.
- Tomatoes - the lycopene neutralizes cancer-causing substances. Ten servings a week may help reduce risk of prostate cancer by half.
- Cabbage, turnips - the phytochemical, phenethyl isothiocyanate, hampers the development of lung cancer.
- Ginger - suppresses the creation of adducts, formed by the reaction of chemical carcinogens with DNA.
- Garlic, onions - the allium vegetables contain organosulphides that lower the risk of gastrointestinal cancers.
- Apples - the caffeic acid increases the production of enzymes that make carcinogens more soluble in water and ultimately ejects them from the body.
- Grapes - the ellagic acid is a scavenger of carcinogens.
- Oranges - the terpenes may prevent lung cancer; while beta-cryptoxanthin is an anti-cancer carotenoid.
Food that is detrimental
- Consumption of red meat-beef, pork and lamb could increase the risk of cancer, especially colorectal, pancreatic, breast, colon and renal cancers.
- Fat is another suspect. Indian sweets contain loads of fat and sugar and digesting them produces bile acids which can transform into substances that promote colon canter. It also causes hormones levels to shoot up and increases the growth of breast and prostate cancers.
- Excessive drinking causes cancer of mouth, throat, oesophagus and liver.
Tips to work fruits and vegetables into your busy schedule
- Put fruits that don't need refrigerating where you can see them. Make a habit of grabbing a few on the way out.
- Keep a bag of your favourite vegetables, cut into sticks, in the freezer. It will last months.
- Keep fruit canned in 100 per cent juice in your kitchen.
- Keep assorted dried fruits like raisins, apricots, peaches, pears, figs and dates, in your desk.
- Keep bottles of fruit juice in the refrigerator instead of aerated drinks.
- Whenever eating out, make it a point to order salads and fruit juice instead of junk food.
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Cancer Research - the light ahead |
Scientific research that is progressing in leaps and bounds will soon change the face of cancer. In this scenario, traditional cancer classification techniques - the size, shape and location of tumors - will fall by the wayside and be replaced by a 'molecular perspective'. Cancer will be identified not by the site, like cervical cancer or breast cancer, but by its molecular defects. This will enable treatment to go with the patient's tumor type rather than its location.
This is possible as scientists are now equipped, through headway in molecular biology and computer science, to delve into the genetic complexity of cancer. Now oncologists are primarily concerned with catching the cancer early, when there's more chance of treating it. However, the scanning technologies used for detecting cancer early are not 100 per cent effective. As cancer moves about the body, it leaves a residue of genes and proteins that are different from that left behind by normal cells. Unravelling this molecular trail of cancer can help detect the disease much before it becomes visible.
The results of these investigations, especially studying the molecular signatures, will help doctors find out which tumors are dangerous and which need treatment. One group of researchers in the US believes that molecular profiling could radically change breast cancer treatment. Right now, nearly all women with breast cancer are put on chemotherapy after surgery to prevent cancer from spreading. Some of them may not need it but there is no mechanism that can tell who needs it and who doesn't. With molecular profiling, it would be possible to say which tumors are dangerous and who needs treatment.
Molecular profiling will also help scientists devise therapies that hit the most vulnerable spot in the tumor. It looks like a new dawn in the treatment of cancer.
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Questions a cancer patient can ask the doctor |
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Glossary |
Antioxidants - Substances, which in small amounts will inhibit the oxidation of other compounds.
Autologous tissue - During breast reconstruction, the tissue that is taken from the patient's body.
Benign - Not cancerous; does not invade nearby tissue or spread to other parts of the body.
Biological Therapy - Treatment to stimulate or restore the ability of the immune system to fight infection and disease. Also known as immunotherapy, biotherapy, or Biological Response Modifier (BRM) therapy.
Buccal Mucosa - Pertaining to the mouth, especially the inner lining of the cheeks.
Carcinogens - Certain chemicals which cause cancer by altering the genetic make-up of the cells.
Chemotherapy - Is a systemic treatment in which chemical substances or drugs are injected into the vein or muscle to kill cancer cells.
Endometrial Cancer - Cancer which occurs within the Uterus.
Lumpectomy - Removal of tumorous lump.
Lymphoma - Malignant tumors of the lymph nodes.
Lymphatic System - The tissues and organs that produce, store, and carry white blood cells that fight infection and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes, and network of thin tubes that carry lymph and white blood cells. These tubes branch, like blood vessels, into all the tissues of the body.
Malignant - Cancerous; spread into the surrounding tissues.
Mammogram - An X-ray of the breasts that can detect tumors in the breast much before they are big enough to be felt by hand.
Mastectomy - Removal of the breast.
Metastasis - Transfer of disease from one organ or part of the body to another, the causative agent having been conveyed by the blood or lymph.
Oncology - Field of knowledge regarding tumors.
Pap Smear Test - Screening test for cervical cancer which detects cancers early and spots precancerous conditions. Also called the Pap Test this procedure involves a few cells being scrapped off the cervix, put on a microscope slide, dyed and examined.
Radiotherapy - A treatment modality for cancer which uses high energy rays that are trained on the cancer cells to stop them from growing and multiplying.
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